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A serum antibody response has not been previously demonstrated after infection withClostridium botulinum. We developed an enzyme immunoassay for measuring serum antibody toC. botulinum toxins A, B, and E. This assay system detected a specific immunoglobulin G and immunoglobulin M antibody response toC. botulinum toxin in two patients with infant botulism.

Serum Antibody Response to Clostridium botulinum Toxin in Infant Botulism