Use of protein A-treated sera in unmasking herpes simplex virus type 1 (HSV-1) immunoglobulin A and identifying HSV-1 immunoglobulin G as the predominant neutralizing antibody | Zendy

J. J. Ratner | Zendy; B A Sanford | Zendy; Kendall O. Smith | Zendy

Open Access

Use of protein A-treated sera in unmasking herpes simplex virus type 1 (HSV-1) immunoglobulin A and identifying HSV-1 immunoglobulin G as the predominant neutralizing antibody

Author(s) -

J. J. Ratner,

B A Sanford,

Kendall O. Smith

Publication year - 1979

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.10.4.415-418.1979

Subject(s) - herpes simplex virus , antibody , virology , immunoglobulin g , immunoglobulin m , radial immunodiffusion , simplexvirus , immunoglobulin a , neutralizing antibody , immunodiffusion , virus , radioimmunoassay , herpesviridae , biology , herpes genitalis , immunology , viral disease , genital herpes , endocrinology

Treatment of human sera with protein A reduced the amounts of immunoglobulin G (IgG), IgA, and IgM detected by radial immunodiffusion. This treatment also decreased the amount of herpes-specific IgG and IgM detected by radioimmunoassay, whereas it increased and even unmasked the amount of herpes-specific IgA detected. Comparison of protein A-treated sera with untreated sera indicated that herpes simplex virus type 1 IgG was responsible for more than 92 to 99% of the serum neutralizing activity.

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