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Meyer, Margaret E. (University of California, Davis). Metabolic characterization of the genusBrucella . V. Relationship of strain oxidation rate ofi -erythritol to strain virulence for guinea pigs. J. Bacteriol.92: 584–588. 1966.—Strain rate of oxidation ofi -erythritol and strain virulence were studied to determine whether or not the two characteristics were related within the speciesBrucella abortus, B. suis , andB. melitensis . The oxidation rate ofi -erythritol was determined manometrically, and strain virulence was assessed by injecting groups of guinea pigs and then recording counts of organisms recovered on culture from spleens 21 and 42 days after inoculation. The range in oxidative rates characteristic of virulent strains in each species was established, and strains displaying oxidative rates representative of the full array of values within the rate ranges were virulence-tested. In addition, a mutant that was capable of oxidizingi -erythritol, obtained from a strain that did not oxidize this substrate, was assessed simultaneously to detect any alterations in virulence of the mutant. The data presented herein warrant the conclusion that strain rate of oxidation ofi -erythritol is unrelated to the virulence of the strain for guinea pigs in the speciesB. abortus, B. suis , andB. melitensis .

journal of bacteriology

Metabolic Characterization of the Genus<i>Brucella</i>V. Relationship of Strain Oxidation Rate of<i>i</i>-Erythritol to Strain Virulence for Guinea Pigs

Metabolic Characterization of the GenusBrucellaV. Relationship of Strain Oxidation Rate ofi-Erythritol to Strain Virulence for Guinea Pigs