EFFECT OF SALMONELLA GALLINARUM ON CERTAIN KREBS CYCLE INTERMEDIATES OF DOMESTIC FOWL

Freeman , B. M. (Houghton Poultry Research Station, Huntingdon, England),and L. G. Chubb . Effect ofSalmonella gallinarum on certain Krebs cycle intermediates of domestic fowl. J. Bacteriol.88: 93–95. 1964.—In chickens infected withSalmonella gallinarum , the citric acid content of the blood rose but that of the liver fell significantly. The former may be due solely to anorexia; the latter is suggested to be a result of the inhibition of the reaction between pyruvic and oxaloacetic acids. Pyruvic acid in the blood remained at its normal level, suggesting that other pathways for its metabolism were being utilized. A rise in the blood α-ketoglutaric acid concentration was also found; this appeared to be a specific response to the infection. These results are compared with data available for other species ofSalmonella .