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Hedgecock, Loyd W. (Veterans Administration Hospital, Kansas City, Mo.). Effect of vaccines prepared fromHistoplasma capsulatum and other yeasts on experimental tuberculosis. J. Bacteriol.82: 115–123. 1961.—Resistance to experimental tuberculosis was enhanced by the injection of a nonviable vaccine prepared fromHistoplasma capsulatum in the mycelial phase but not by the organism in the yeast phase. Acquired resistance was established within 7 days or less and usually maintained for at least 29 days. When both mycelium vaccine ofH. capsulatum and a vaccine prepared from tubercle bacilli were utilized in vaccination, the results were additive (in terms of acquired resistance) provided that an interval of 3 weeks was maintained between injection of each of the vaccines.Resistance to tuberculosis was also demonstrable 14 days after the injection of nonviable preparations ofBrucella abortus andCryptococcus neoformans , as well as by yeast and mycelial vaccines ofBlastomyces dermatitidis andSporotrichum schenckii . Resistance decreased significantly when the animals were challenged 29 days after vaccination, with the exception of those injected with the yeast phase ofB. dermatitidis .

EFFECT OF VACCINES PREPARED FROMHISTOPLASMA CAPSULATUMAND OTHER YEASTS ON EXPERIMENTAL TUBERCULOSIS