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When grown in rich medium,Escherichia coli exhibits a drastic reduction of the number of viable cells at the beginning of stationary phase. The decline of cell viability was retarded by disruption of thessnA gene, which was identified as a gene subject to RpoS-dependent negative regulation. Moreover,ssnA expression was induced at the time of decline of cell viability at early stationary phase. The viability decline was augmented in therpoS background, and this augmentation was suppressed byssnA mutation. Cloning of thessnA gene in a multicopy plasmid, pBR322, caused small colony formation and slow growth in liquid medium. Cells harboring thessnA clone showed aberrant morphology that included enlarged and filamentous shapes. The gene product was identified as a 44-kDa soluble protein, but its function could not be deduced by homology searching. From these results, we conclude thatssnA is expressed in response to a phase-specific signal(s) and that its expression level is controlled by RpoS, by a mechanism which may contribute to determination of cell number in the stationary phase.

journal of bacteriology

Characterization of the <i>ssnA</i> Gene, Which Is Involved in the Decline of Cell Viability at the Beginning of Stationary Phase in <i>Escherichia coli</i>

Characterization of the ssnA Gene, Which Is Involved in the Decline of Cell Viability at the Beginning of Stationary Phase in Escherichia coli