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Glucose repressed hemolysin production inVibrio vulnificus . Promoter activity of the hemolysin gene,vvh , assessed with avvh-luxCDABE transcriptional fusion, required cyclic AMP (cAMP) and cAMP receptor protein (CRP) inEscherichia coli . Hemolysin production inV. vulnificus increased after the addition of cAMP and was undetectable in a putativecrp mutant, suggesting thatvvh is also regulated by cAMP-CRP inV. vulnificus .

Evidence that Expression of the Vibrio vulnificus Hemolysin Gene Is Dependent on Cyclic AMP and Cyclic AMP Receptor Protein