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The role of ςB , an alternative sigma factor ofStaphylococcus aureus , has been characterized in response to environmental stress, starvation-survival and recovery, and pathogenicity. ςB was mainly expressed during the stationary phase of growth and was repressed by 1 M sodium chloride. AsigB insertionally inactivated mutant was created. In stress resistance studies, ςB was shown to be involved in recovery from heat shock at 54°C and in acid and hydrogen peroxide resistance but not in resistance to ethanol or osmotic shock. Interestingly,S. aureus acquired increased acid resistance when preincubated at a sublethal pH 4 prior to exposure to a lethal pH 2. This acid-adaptive response resulting in tolerance was mediated viasigB . However, ςB was not vital for the starvation-survival or recovery mechanisms. ςB does not have a major role in the expression of the global regulator of virulence determinant biosynthesis, staphylococcal accessory regulator (sarA ), the production of a number of representative virulence factors, and pathogenicity in a mouse subcutaneous abscess model. However, SarA upregulatessigB expression in a growth-phase-dependent manner. Thus, ςB expression is linked to the processes controlling virulence determinant production. The role of ςB as a major regulator of the stress response, but not of starvation-survival, is discussed.

journal of bacteriology

The <i>Staphylococcus aureus</i> Alternative Sigma Factor ς <sup>B</sup> Controls the Environmental Stress Response but Not Starvation Survival or Pathogenicity in a Mouse Abscess Model

The Staphylococcus aureus Alternative Sigma Factor ς B Controls the Environmental Stress Response but Not Starvation Survival or Pathogenicity in a Mouse Abscess Model

The Staphylococcus aureus Alternative Sigma Factor ς ^B Controls the Environmental Stress Response but Not Starvation Survival or Pathogenicity in a Mouse Abscess Model