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Two differentially regulated catalase genes have been identified in the fungusAspergillus nidulans . ThecatA gene belongs to a class whose transcripts are specifically induced during asexual sporulation (conidiation) and encodes a catalase accumulated in conidia. Using a developmental mutant affected in thebrlA gene, which is unable to form conidia but capable of producing sexual spores (ascospores), we demonstrated that thecatA mRNA accumulated during induction of conidiation but did not produce CatA protein. In contrast, high levels of catalase A activity were detected in the ascospores produced by this mutant, indicating that thecatA gene is posttranscriptionally regulated. The same type of regulation was observed for acatA ::lacZ translational gene fusion, suggesting that thecatA message 5′ untranslated region could be involved in translational control during development. In a wild-type strain, β-galactosidase activity driven from thecatA ::lacZ gene fusion was low in hyphae and increased 50-fold during conidiation and 620-fold in isolated conidia. Consistent with this finding spatial expression of the reporter gene was restricted to metulae, phialides, and conidia. Conidium-associated expression was maintained in astuA mutant, in which the conidiophore cell pattern is severely deranged.catA mRNA accumulation was also observed when vegetative mycelia was subject to oxidative, osmotic, and nitrogen or carbon starvation stress. Nevertheless, catalase A activity was restricted to the conidia produced under nutrient starvation. Our results provide support for a model in which translation of thecatA message, accumulated during conidiation or in response to different types of stress, is linked to the morphogenetic processes involved in asexual and sexual spore formation. Our findings also indicate thatbrlA -independent mechanisms regulate the expression of genes encoding spore-specific products.

Posttranscriptional Control Mediates Cell Type-Specific Localization of Catalase A during Aspergillus nidulans Development