English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

InEscherichia coli the genes encoding the anaerobic fumarate respiratory system are transcriptionally regulated by C4 -dicarboxylates. The regulation is effected by a two-component regulatory system, DcuSR, consisting of a sensory histidine kinase (DcuS) and a response regulator (DcuR). DcuS and DcuR are encoded by thedcuSR genes (previouslyyjdHG ) at 93.7 min on the calculatedE. coli map. Inactivation of thedcuR anddcuS genes caused the loss of C4 -dicarboxylate-stimulated synthesis of fumarate reductase (frdABCD genes) and of the anaerobic fumarate-succinate antiporter DcuB (dcuB gene). DcuS is predicted to contain a large periplasmic domain as the supposed site for C4 -dicarboxylate sensing. Regulation by DcuR and DcuS responded to the presence of the C4 -dicarboxylates fumarate, succinate, malate, aspartate, tartrate, and maleate. Since maleate is not taken up by the bacteria under these conditions, the carboxylates presumably act from without. Genes of the aerobic C4 -dicarboxylate pathway encoding succinate dehydrogenase (sdhCDAB ) and the aerobic succinate carrier (dctA ) are only marginally or negatively regulated by the DcuSR system. The CitAB two-component regulatory system, which is highly similar to DcuSR, had no effect on C4 -dicarboxylate regulation of any of the genes.

Fumarate Regulation of Gene Expression in Escherichia coli by the DcuSR ( dcuSR Genes) Two-Component Regulatory System