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Expression of the principal chaperones of the heat shock stimulon ofStreptomyces albus G are under the negative control of different repressors. ThednaK operon is regulated byhspR , the last gene of the operon (dnaK-grpE-dnaJ-hspR ).hsp18 , encoding a member of the small heat shock protein family, is regulated byorfY , which is in the opposite orientation upstream ofhsp18 . ThegroES-groEL1 operon and thegroEL2 gene are regulated differently. They present tandem copies of the CIRCE element found in the 5′ region of many heat shock genes and shown to act inBacillus subtilis as an operator for a repressor encoded byhrcA (hrc stands for heat regulation at CIRCE). We report the identification inS. albus of a new heat shock operon containinghrcA anddnaJ homologs. Disruption ofhrcA increased the transcription of thegroES-groEL1 operon and of thegroEL2 gene. These features were lost when the mutant was complemented intrans by an intact copy ofhrcA . Despite considerable accumulation of the GroE chaperones in thehrcA mutant, there was no effect on formation of the aerial mycelium and sporulation, indicating that neitherhrcA nor the level ofgroE gene expression is directly involved in the regulation ofStreptomyces morphological differentiation.

hrcA , Encoding the Repressor of the groEL Genes in Streptomyces albus G , Is Associated with a Second dnaJ Gene