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The relationship of methionine to the inhibition caused byS -adenosylmethionine andS -adenosylhomocysteine in strains containing thesai-1 mutation has been investigated and shown to affect indirectly the survival of the mutants. The ability of the mutants to take up both inhibitors is similar to that of the wild-type cells. The mutant also retains the ability to hydrolyzeS -adenosylhomocysteine and incorporate the hydrolytic products into the various cellular fractions. Maximal inhibition of thesai-1 mutants occurs at an extracellular concentration of 0.005 mm S -adenosylmethionine and 0.025 to 0.05 mm S -adenosylhomocysteine when the cellular concentration is 0.05 mg (dry weight) per ml. The results suggest that thesai-1 mutation affects reaction(s) either not associated with methionine biosynthesis, or methionine synthesis and at least one other critical cellular function.

journal of bacteriology

sai-1 Mutation in Saccharomyces cerevisiae : Characteristics of Inhibition by S -Adenosylmethionine and S -Adenosylhomocysteine and Protection by Methionine