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Double mutants ofSerratia marcescens resistant to isoleucine hydroxamate and α-aminobutyric acid accumulated large amounts of isoleucine in a salts-sugar medium and lacked both feedback inhibition and repression of the isoleucine biosynthesis.

Isoleucine Accumulation by Regulatory Mutants of Serratia marcescens : Lack of Both Feedback Inhibition and Repression