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α-Aminobutyric acid, norvaline, and norleucine, which are analogues of branched-chain amino acids, inhibited the growth ofSerratia marcescens . The inhibitory effect of these three analogues was counteracted by branched-chain amino acids. A number of mutants resistant to these analogues were isolated. α-Aminobutyric acid-resistant (abu-r ) mutants markedly accumulatedl -valine in the culture medium, but the other analogue-resistant mutants did not. Acetohydroxy acid synthetase, which seems to be rate-limiting for the biosynthesis ofl -valine, was derepressed inabu-r mutants. One of theabu-r mutants, no. 140, which accumulated over 8 mg ofl -valine per ml, had about a 20-fold increase in the enzyme level. Most of theabu-r mutants had acetohydroxy acid synthetase activity which was sensitive to feedback inhibition byl -valine to the same extent as in the parent strain. However, the enzyme of two ofabu-r mutants was less sensitive tol -valine, and one of the two was the best valine accumulator.

Valine Accumulation by α-Aminobutyric Acid-Resistant Mutants of Serratia marcescens