English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Upon entry into the host,Salmonella enterica strains are presumed to encounter an iron-restricted environment. Consequently, these bacteria have evolved a variety of often-redundant high-affinity acquisition systems to obtain iron in this restricted environment. We have identified an iron transport system that is encoded within the centisome 63 pathogenicity island ofSalmonella typhimurium . The nucleotide composition of this locus is significantly different from that of the rest of this pathogenicity island, suggesting a different ancestry and a mosaic structure for this region of theS. typhimurium chromosome. This locus, designatedsit , consists of four open reading frames which encode polypeptides with extensive homology to theyfe ABC iron transport system ofYersinia pestis , as well as other ABC transporters. ThesitA gene encodes a putative periplasmic binding protein,sitB encodes an ATP-binding protein, andsitC andsitD encode two putative permeases (integral membrane proteins). This operon is capable of complementing the growth defect of the enterobactin-deficientEscherichia coli strain SAB11 in iron-restricted minimal medium. Transcription of thesit operon is repressed under iron-rich growth conditions in afur -dependent manner. Introduction of asitBCD deletion into wild-typeS. typhimurium resulted in no apparent growth defect in either nutrient-rich or minimal medium and no measurable virulence phenotype. These results further support the existence of redundant iron uptake systems inS. enterica .

Salmonella typhimuriumEncodes a Putative Iron Transport System within the Centisome 63 Pathogenicity Island