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Theileria parasites infect and transform bovine leukocytes. We have analyzed laboratory-establishedTheileria sp.-infected leukocyte lines and observed that transformed macrophages express CD5. Low-level expression of CD5 by macrophages was further confirmed on three independentTheileria annulata clinical isolates from Tunisia. Interestingly, the fourth CD5+ clinical isolate (MB2) was morphologically different, expressed surface immunoglobulin M (IgM) and BoLA class II, and had rearranged Ig light-chain genes. To demonstrate that MB2 did indeed contain CD5+ B cells, individual clonal lines were obtained by limiting dilution, and CD5 expression and Ig gene rearrangement were confirmed. This suggests that in natural infectionsT. annulata can invade and transform CD5+ B cells.

Theileria annulata in CD5 + Macrophages and B1 B Cells

Theileria annulata in CD5 ⁺ Macrophages and B1 B Cells