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Borrelia burgdorferi -induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for their response to infection withB. burgdorferi . E and P selectins were not required for the control ofB. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.

E and P Selectins Are Not Required for Resistance to Severe Murine Lyme Arthritis