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From a collection of 2,800 Tn5 -TC1 transposon mutants ofSalmonella typhimurium F98, 18 that showed reduced intestinal colonization of 3-week-old chicks were identified. The sites of transposon insertion were determined for most of the mutants and included insertions in the lipopolysaccharide biosynthesis genesrfaK ,rfaY ,rfbK , andrfbB and the genesdksA ,clpB ,hupA , andsipC . In addition, identification was made of an insertion into a novel gene that encodes a protein showing similarity to the IIC component of the mannose class of phosphoenolpyruvate-carbohydrate phosphotransferase systems, which we putatively calledptsC . Transduction of most of the transposon mutations to a freshS. typhimurium F98 genetic background and construction of defined mutations in therfbK ,dksA ,hupA ,sipC , andptsC genes ofS. typhimurium F98 supported the role in colonization of all but thepts locus. The virulence of therfbK ,dksA ,hupA ,sipC , andptsC defined mutants andclpB andrfaY transductants in 1-day-old chicks was tested. All but theptsC andrfaY mutants were attenuated for virulence. A number of other phenotypes associated with some of the mutations are described.

infection and immunity

Identification of <i>Salmonella typhimurium</i> Genes Required for Colonization of the Chicken Alimentary Tract and for Virulence in Newly Hatched Chicks

Identification of Salmonella typhimurium Genes Required for Colonization of the Chicken Alimentary Tract and for Virulence in Newly Hatched Chicks