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The effect of immunization with either aPorphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu-PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate fromP. gingivalis could potentially be developed as a vaccine against periodontal infection byP. gingivalis.

infection and immunity

Capsular Polysaccharide-Fimbrial Protein Conjugate Vaccine Protects against<i>Porphyromonas gingivalis</i>Infection in SCID Mice Reconstituted with Human Peripheral Blood Lymphocytes

Capsular Polysaccharide-Fimbrial Protein Conjugate Vaccine Protects againstPorphyromonas gingivalisInfection in SCID Mice Reconstituted with Human Peripheral Blood Lymphocytes