Open AccessDifferential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro
Author(s) -
Yifan Zhan,
Christina Cheers
Publication year - 1995
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.63.2.720-723.1995
Subject(s) - biology , listeria monocytogenes , microbiology and biotechnology , in vitro , macrophage , intracellular parasite , tumor necrosis factor alpha , interferon gamma , bacteria , brucella , cytokine , interleukin , immunology , virology , brucellosis , immune system , genetics , biochemistry
Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines.
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