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The effects of maltose on production and secretion of virulence factors of Vibrio cholerae in strain X28214, classical biotype, and in maltose-defective transposon mutants constructed from this strain were characterized. Maltose was found to inhibit secretion of cholera toxin and to reduce production of the mannose-sensitive hemagglutinin and the soluble hemagglutinin-protease. In contrast, the amount of toxin-coregulated pilus was increased in the presence of maltose. The maltose effect was apparently mediated by genes of the maltose regulon, since inactivation of the malQ or malF gene of V. cholerae by transposon insertion was found to affect production and secretion of the same virulence factors that were responsive to maltose. The malQ and malF mutants showed, in addition, reduced virulence in an infant-mouse model. These results suggest that maltose may have a significant regulatory role in the production of virulence factors and that an intact maltose regulon is needed for full virulence of V. cholerae.

The maltose regulon of Vibrio cholerae affects production and secretion of virulence factors