Open AccessEffect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae
Author(s) -
James C. Paton,
R.A.C. Lock,
D. J. Hansman
Publication year - 1983
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.40.2.548-552.1983
Subject(s) - pneumolysin , streptococcus pneumoniae , biology , microbiology and biotechnology , virulence , pneumococcal infections , toxin , immunization , streptococcaceae , cytolysis , pathogenicity , immunology , virology , antigen , antibiotics , gene , cytotoxic t cell , in vitro , biochemistry
The role of the cytolytic toxin pneumolysin in the pathogenicity of Streptococcus pneumoniae was investigated. Pneumolysin was purified to homogeneity and used to immunize mice. When these mice were subsequently challenged via the nasal route with virulent S. pneumoniae, they survived significantly longer than control mice. The mean survival times were 5.52 and 2.48 days for immunized and control mice, respectively. This work provides direct evidence for the involvement of pneumolysin in pneumococcal pathogenicity.
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