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Congenitally athymic (nude) mice exhibited an anomalous high resistance against infections with the facultative intracellular parasite Listeria monocytogenes and other bacterial pathogens. Protection against lethal infection was demonstrated to result from the presence of naturally occurring activated macrophages in the reticuloendothelial organs of the nude mice. This was exemplified after intravenous challenge by enhanced bacterial clearance from the blood and augmented bacterial killing in the spleens and livers of nude mice as compared with immunologically competent control mice. Resident peritoneal macrophages of nude mice were not activated in terms of phagocytic, bactericidal, or tumoricidal potential. The development of activated fixed tissue macrophages appears to arise as a result of the T-lymphocyte deficiency since thymus implantation abrogated the enhanced resistance of nude mice. Antibiotic elimination of intestinal bacteria also modified resistance to bacterial infection, indicating a role of environmental factors on macrophage activation. Several possible mechanisms leading to macrophage activation and heightened resistance to infection in nude mice are offered.

Anomalous high native resistance to athymic mice to bacterial pathogens