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An Escherichia coli K-12 strain bearing the plasmids R1 or R100 was more resistant to the bactericidal activity of normal rabbit serum than was the same strain without a plasmid. When the plasmid R100 was transferred to several K-12 strains, the strains acquired resistance to serum bactericidal activity.

Plasmid-mediated resistance to the bactericidal effects of normal rabbit serum