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HBc Ag was detected by fluorescent antibody in liver biopsies taken from chronic hepatitis B surface antigen (HBs Ag) carriers having e antigen in their sera. HBc Ag could not be detected in liver biopsies from similar individuals having e antibody in their sera.

Correlation between fluorescent antibody detection of hepatitis B core antigen in liver biopsies and the presence of e antigen in serum