Open AccessProtein Kinase C-α Is a Gatekeeper of Cryptosporidium Sporozoite Adherence and Invasion
Author(s) -
Sayo McCowin,
William A. Petri,
Chelsea Marie
Publication year - 2022
Publication title -
infection and immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.508
H-Index - 220
eISSN - 1070-6313
pISSN - 0019-9567
DOI - 10.1128/iai.00679-21
Subject(s) - cryptosporidium parvum , protein kinase c , biology , cryptosporidium , protein kinase a , in vitro , gentamicin protection assay , mediator , intracellular , kinase , immunology , virology , microbiology and biotechnology , gene , biochemistry , feces , western blot
Cryptosporidium infection is a leading cause of diarrhea-associated morbidity and mortality in young children globally. Single nucleotide polymorphisms (SNPs) in the human protein kinase C-α (PRKCA ) gene region have been associated with susceptibility to cryptosporidiosis.