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open-access-imgOpen AccessSpiramycin Treatment of Toxoplasma gondii Infection in Pregnant Women Impairs the Production and the Avidity Maturation of T. gondii -Specific Immunoglobulin G Antibodies
Author(s)
Valeria Meroni,
Francesca Genco,
Carmine Tinelli,
P. Lanzarini,
Lina Bollani,
Mauro Stronati,
Eefke Petersen
Publication year2009
Publication title
clinical and vaccine immunology
Resource typeJournals
PublisherAmerican Society for Microbiology
The aim of the study was to evaluate the influence of treatment with spiramycin on the increase of immunoglobulin G (IgG) titers and IgG avidity indexes (AI) in pregnant women with seroconversion from the beginning of therapy until delivery and after delivery. This group was compared with adult patients with recently acquired untreated toxoplasmosis. One hundred four samples from 32 pregnant women with seroconversion for toxoplasmosis and/or very low IgG AI were followed from the beginning of therapy with spiramycin until delivery. Twenty-nine women were further followed some months after delivery and interruption of therapy. Thirty-eight samples from 16 untreated, nonpregnant patients were evaluated as the control group. TheToxoplasma gondii -specific IgG antibody and theT. gondii -specific IgG AI were significantly delayed in pregnant women receiving therapy compared to nonpregnant, untreated controls, and the findings were consistent with the results of assays from two different manufacturers. TheT. gondii -specific IgG AI increased in pregnant women after they gave birth. Avidity maturation is delayed during pregnancy and treatment, and low-avidity antibodies in pregnant women within 3 to 4 months cannot be taken as a sign of infection.
Subject(s)antibiotics , antibody , avidity , biology , erythromycin , genetics , immunoglobulin g , immunology , medicine , microbiology and biotechnology , pregnancy , seroconversion , spiramycin , titer , toxoplasma gondii , toxoplasmosis , virology
Language(s)English
SCImago Journal Rank1.649
H-Index77
eISSN1556-6811
pISSN1556-679X
DOI10.1128/cvi.00253-09

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