Open AccessLack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused byStaphylococcus aureus
Author(s) -
Catrin E. Moore,
Shelley Segal,
Anthony R. Berendt,
Adrian V. S. Hill,
Nicholas Day
Publication year - 2004
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.11.6.1194-1197.2004
Subject(s) - staphylococcus aureus , toll like receptor , disease , toll , immunology , microbiology and biotechnology , medicine , biology , receptor , genetics , bacteria , innate immune system
To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found.