Open AccessValue of the Concomitant Use of Complement Fixation and Immunodiffusion Tests in the Diagnosis of Coccidioidomycosis
Author(s) -
Leo Kaufman,
Maxine J. Clark
Publication year - 1974
Publication title -
applied microbiology
Language(s) - English
Resource type - Journals
ISSN - 0003-6919
DOI - 10.1128/am.28.4.641-643.1974
Subject(s) - complement fixation test , immunodiffusion , titer , medicine , serology , antibody , immunology , complement (music) , biology , gene , complementation , biochemistry , phenotype
Complement fixation titers of 1:2 and 1:4 with coccidioidin are not always of diagnostic significance. The concurrent use of the complement fixation and immunodiffusion tests is an effective means for specific serologic diagnosis of coccidioidomycosis in patients with low levels of complement-fixing antibodies. In routine testing, it is recommended that only sera that are negative for complement-fixing antibodies at 1:8 but positive in the immunodiffusion test with coccidioidin be selected for titration at the 1:2 and 1:4 levels.
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