Open AccessSimple Method of Evaluating Scrapie in Mice
Author(s) -
Kenneth W. Cochran,
Lois B. Allen
Publication year - 1970
Publication title -
applied microbiology
Language(s) - English
Resource type - Journals
ISSN - 0003-6919
DOI - 10.1128/am.20.1.72-74.1970
Subject(s) - scrapie , disease , simple (philosophy) , sequence (biology) , biology , computational biology , medicine , pathology , genetics , prion protein , philosophy , epistemology
Mice in advanced scrapie characteristically clasp their hindlegs together. As the disease progresses into the clasping stage, mice exhibit a sequence of identifiable hindleg reactions which have categorized and assigned relative scores permitting objective, quantitative evaluation of disease.
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