Open AccessIsolation and Characterization of Antibiotic LL-AC541
Author(s) -
V. Zbinovsky,
W. Hausmann,
E. R. Wetzel,
Donald B. Borders,
E. L. Patterson
Publication year - 1968
Publication title -
applied microbiology
Language(s) - English
Resource type - Journals
ISSN - 0003-6919
DOI - 10.1128/am.16.4.614-616.1968
Subject(s) - antibiotics , streptomyces hygroscopicus , isolation (microbiology) , fermentation , antimicrobial , microbiology and biotechnology , chemistry , biology , streptomyces , bacteria , food science , genetics
A new basic, water-soluble antibiotic designated LL-AC541, produced by a strain ofStreptomyces hygroscopicus (NRRL 3111), was isolated as a hydrochloride salt; [α]D 25 , — 58°, melting point, 200 to 215 C (decomposition). It is structurally related to streptothricin but does not contain β-lysine. Isolation procedures, physicochemical properties, antimicrobial spectrum, and in vivo testing results are presented. Another very closely related antibiotic obtained from the same fermentation is briefly described.
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