Open AccessDNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae
Author(s) -
Takashi Deguchi,
Mitsuru Yasuda,
Makoto Asano,
Kouji Tada,
Hisato Iwata,
Hisao Komeda,
Takayuki Ezaki,
Isao Saito,
Yukimichi Kawada
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.2.561
Subject(s) - neisseria gonorrhoeae , dna gyrase , microbiology and biotechnology , quinolone , asparagine , escherichia coli , serine , neisseria , biology , aspartic acid , phenylalanine , neisseriaceae , bacteria , amino acid , genetics , antibiotics , gene , phosphorylation
Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.