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We examined the effects of pH and incubation in a CO(2)-containing atmosphere on the activity of erythromycin against 81 strains of the Bacteroides fragilis group. A striking reduction in erythromycin activity was noted when the pH decreased below 7.0 and when the organisms were incubated with CO(2).

Effect of Carbon Dioxide and pH on Susceptibility of Bacteroides fragilis Group to Erythromycin