Open AccessN 6 -methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5
Author(s) -
Jeffrey A. Purslow,
Thanh Tuan Nguyen,
Balabhadra Khatiwada,
Aayushi Singh,
Vincenzo Venditti
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abi8215
Subject(s) - demethylase , n6 methyladenosine , decarboxylation , epigenetics , biology , microbiology and biotechnology , carcinogenesis , chemistry , biochemistry , stereochemistry , biophysics , gene , methylation , methyltransferase , catalysis
NMR and MD simulations provide insights into the mechanisms governing activation and substrate selectivity of Alkbh5.