Open AccessReconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
Author(s) -
Chunmei Chang,
Xiaoshan Shi,
Liv Jensen,
Adam L. Yokom,
Dorotea Fracchiolla,
Sascha Martens,
James H. Hurley
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abg4922
Subject(s) - lipid anchored protein , autophagy , microbiology and biotechnology , ulk1 , biogenesis , atg8 , receptor , ubiquitin , biology , kinase , chemistry , protein kinase a , biochemistry , gene , apoptosis , ampk
Reconstitution experiments show how different cargo receptors engage the autophagy machinery in unique ways to lipidate LC3.