Open AccessUltrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations
Author(s) -
Xin Peng,
Xianfeng Xia,
Xiayi Xu,
Xuefeng Yang,
Boguang Yang,
Pengchao Zhao,
Weihao Yuan,
Philip Wai Yan Chiu,
Liming Bian
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abe8739
Subject(s) - bioadhesive , polyacrylic acid , adhesion , materials science , tissue adhesion , adhesive , polymer , sealant , nanotechnology , biomedical engineering , composite material , layer (electronics) , medicine
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an acute clinical demand because of the interfering interfacial water and limited adhesive-tissue interactions. Here we report a self-gelling and adhesive polyethyleneimine and polyacrylic acid (PEI/PAA) powder, which can absorb interfacial water to form a physically cross-linked hydrogel in situ within 2 seconds due to strong physical interactions between the polymers. Furthermore, the physically cross-linked polymers can diffuse into the substrate polymeric network to enhance wet adhesion. Superficial deposition of PEI/PAA powder can effectively seal damaged porcine stomach and intestine despite excessive mechanical challenges and tissue surface irregularities. We further demonstrate PEI/PAA powder as an effective sealant to enhance the treatment outcomes of gastric perforation in a rat model. The strong wet adhesion, excellent cytocompatibility, adaptability to fit complex sites, and easy synthesis of PEI/PAA powder make it a promising bioadhesive for numerous biomedical applications.