Open AccessAging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
Author(s) -
Sandro Dá Mesquita,
Jasmin Herz,
Morgan Wall,
Taitea Dykstra,
Kalil Alves de Lima,
Geoffrey T. Norris,
Nisha Dabhi,
Tatiana Kennedy,
Wendy Baker,
Jonathan Kipnis
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abe4601
Subject(s) - neuroinflammation , glymphatic system , dysfunctional family , cognition , amyloid (mycology) , medicine , neuroscience , pathology , microglia , cognitive decline , inflammation , psychology , immunology , dementia , cerebrospinal fluid , disease , psychiatry
Dysfunctional meningeal immunity is associated with cognitive decline, impaired glymphatics, and enhanced Alzheimer’s pathology.