Open AccessBBB pathophysiology–independent delivery of siRNA in traumatic brain injury
Author(s) -
Wen Li,
Jianhua Qiu,
Xiangling Li,
Sezin Aday,
Jingdong Zhang,
Grace Conley,
Jun Xu,
John Joseph,
Haoyue Lan,
Robert Langer,
Rebekah Mannix,
Jeffrey M. Karp,
Nitin Joshi
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abd6889
Subject(s) - traumatic brain injury , small interfering rna , blood–brain barrier , gene silencing , drug delivery , medicine , pathophysiology , drug , pharmacology , neuroscience , nanotechnology , chemistry , central nervous system , materials science , biology , rna , pathology , gene , biochemistry , psychiatry
We describe a nanoparticle platform for brain delivery of nucleic acid–based therapeutics to treat TBI.