Open AccessSynthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
Author(s) -
Kuoyuan Cheng,
Nishanth Ulhas Nair,
Joo Sang Lee,
Eytan Ruppin
Publication year - 2021
Publication title -
science advances
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.928
H-Index - 146
ISSN - 2375-2548
DOI - 10.1126/sciadv.abc2100
Subject(s) - carcinogenesis , synthetic lethality , cancer , biology , gene , transcriptome , suppressor , cancer research , dna methylation , tumor suppressor gene , cancer cell , carcinogen , genetics , gene expression , dna repair
Expression pattern of synthetic lethality genes is a previously unknown factor associated with cancer risk across human tissues.