Open AccessMetabolic outcomes and renal function after simultaneous kidney/pancreas transplantation compared with kidney transplantation alone for type 2 diabetes mellitus patients
Author(s) -
Fu Yingxin,
Cao Yu,
Wang Hui,
Zhao Jie,
Wang Zhen,
Mo Chunbai,
Shi Xiaofeng,
Feng Gang,
Song Wenli
Publication year - 2021
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13892
Subject(s) - medicine , renal function , transplantation , urology , kidney transplantation , glycated hemoglobin , diabetes mellitus , nephrology , kidney disease , pancreas transplantation , type 2 diabetes mellitus , kidney , type 2 diabetes , gastroenterology , surgery , endocrinology
Summary In this study, we aimed to compare the metabolic outcomes, renal function, and survival outcomes of simultaneous pancreas and kidney transplantation (SPK) and kidney transplantation alone (KTA) among end‐stage kidney disease (ESKD) patients with type II diabetes mellitus (T2DM). Patients with ESKD and T2DM who underwent KTA ( n = 85) or SPK ( n = 71) in a transplant center were retrospectively reviewed. Metabolic profiles, renal function, and survival outcomes were assessed repeatedly at different follow‐up time points. Propensity score procedures were applied to enhance between‐group comparability. The levels of renal and metabolic outcomes between SPK and KTA over time were examined and analyzed using mixed‐model repeated‐measures approaches. The median follow‐up period was 1.8 years. Compared with KTA, SPK resulted in superior metabolic outcomes and renal function, with lower levels of glycated hemoglobin (HbA1c; P = 0.0055), fasting blood glucose ( P < 0.001), triglyceride ( P = 0.015), cholesterol ( P = 0.0134), low‐density lipoprotein ( P = 0.0161), and higher estimated glomerular filtration rate (eGFR; P < 0.001). SPK provided better metabolic outcomes and renal function. The survival outcomes of the recipients and grafts were comparable between the two groups.