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The genomic landscape of blood groups in Indigenous Australians in remote communities
Author(s) -
Jadhao Sudhir,
Hoy Wendy,
Lee Simon,
Patel Hardip R.,
McMorran Brendan J.,
Flower Robert L.,
Nagaraj Shivashankar H.
Publication year - 2022
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16873
Subject(s) - abo blood group system , indigenous , population , phenotype , blood transfusion , cohort , biology , h antigen , medicine , demography , immunology , genetics , antigen , gene , ecology , environmental health , sociology
Red blood cell (RBC) membrane-associated blood group systems are clinically significant. Alloimmunisation is a persistent risk associated with blood transfusion owing to the antigen polymorphisms among these RBC-associated blood groups. Next-generation sequencing (NGS) offers an opportunity to characterize the blood group variant profile of a given individual. Australia comprises a large multiethnic population where most blood donors are Caucasian and blood group variants remain poorly studied among Indigenous Australians. In this study, we focused on the Tiwi Islanders, who have lived in relative isolation for thousands of years.