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SARS‐CoV‐2 infection of Chinese hamsters ( Cricetulus griseus ) reproduces COVID‐19 pneumonia in a well‐established small animal model
Author(s) -
Bertzbach Luca D.,
Vladimirova Daria,
Dietert Kristina,
Abdelgawad Azza,
Gruber Achim D.,
Osterrieder Nikolaus,
Trimpert Jakob
Publication year - 2021
Publication title -
transboundary and emerging diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.392
H-Index - 63
eISSN - 1865-1682
pISSN - 1865-1674
DOI - 10.1111/tbed.13837
Subject(s) - hamster , context (archaeology) , biology , virology , pneumonia , pandemic , mesocricetus , chinese hamster , covid-19 , coronavirus , vaccination , immunology , disease , medicine , infectious disease (medical specialty) , genetics , pathology , in vitro , paleontology , microbiology and biotechnology
The SARS‐CoV‐2 pandemic has caused a yet unresolved global crisis. Effective medical intervention by vaccination or therapy seems to be the only possibility to control the pandemic. In this context, animal models are an indispensable tool for basic and applied research to combat SARS‐CoV‐2 infection. Here, we established a SARS‐CoV‐2 infection model in Chinese hamsters suitable for studying pathogenesis of the disease as well as pre‐clinical testing of vaccines and therapies. This species of hamster is susceptible to SARS‐CoV‐2 infection as demonstrated by robust virus replication in the upper and lower respiratory tract accompanied by bronchitis and pneumonia as well as significant body weight loss following infection. The Chinese hamster features advantages compared to the Syrian hamster model, including more pronounced clinical symptoms, its small size, well‐characterized genome, transcriptome and translatome data and availability of molecular tools.