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We characterized 549 new human leukocyte antigen ( HLA ) class I and class  II  alleles found in newly registered stem cell donors as a result of high‐throughput  HLA  typing. New alleles include 101  HLA ‐A, 132  HLA ‐B, 105  HLA ‐C, 2  HLA‐DRB1 , 89  HLA‐DQB1  and 120  HLA‐DPB1  alleles. Mainly, new alleles comprised single nucleotide variations when compared with homologous sequences. We identified nonsynonymous nucleotide mutations in 70.7% of all new alleles, synonymous variations in 26.4% and nonsense substitutions in 2.9% (null alleles). Some new alleles (55, 10.0%) were found multiple times,  HLA‐DPB1  alleles being the most frequent among these. Furthermore, as several new alleles were identified in individuals from ethnic minority groups, the relevance of recruiting donors belonging to such groups and the importance of ethnicity data collection in donor centers and registries is highlighted.

Detection of 549 new HLA alleles in potential stem cell donors from the United States, Poland and Germany