Open AccessHigh‐frequency ultrasound for differentiation between high‐risk basal cell carcinoma and cutaneous squamous cell carcinoma
Author(s) -
Chen ZiTong,
Yan JianNa,
Zhu AnQi,
Wang LiFan,
Wang Qiao,
Li Liang,
Guo LeHang,
Li XiaoLong,
Xu HuiXiong
Publication year - 2022
Publication title -
skin research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.521
H-Index - 69
eISSN - 1600-0846
pISSN - 0909-752X
DOI - 10.1111/srt.13121
Subject(s) - high frequency ultrasound , basal cell , basal cell carcinoma , ultrasound , carcinoma , medicine , pathology , basal (medicine) , oncology , cancer research , radiology , insulin
Abstract Background The similar visual appearance of high‐risk basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) may cause confusion for diagnosis. High‐frequency ultrasound (HFUS) may provide additional intralesional information and thus help to distinguish them. Method In this retrospective study, we analyzed the clinical characteristics, HFUS grayscale, and color Doppler flow imaging (CDFI) features of pathologically confirmed high‐risk BCC and cSCC lesions ( n = 65 vs n = 68). Subsequently, discrimination models based on the significant HFUS features were established. Results Between high‐risk BCC and cSCC lesions, the HFUS grayscale features of the lesion size (10.0 mm vs 17.4 mm), thickness (3.1 mm vs 5.9 mm), internal hyperechoic spots (80.0% vs 23.5%), and posterior acoustic shadowing (16.9% vs 66.2%) were statistically different (all p < 0.001). As for the CDFI features, high‐risk BCC lesions mainly appeared as pattern II (47.7%), while cSCC lesions mainly appeared as pattern III (66.2%). Based on the above five features, an optimal discrimination model was established with a sensitivity of 91.2%, a specificity of 87.7%, and an accuracy of 89.5%. Conclusion HFUS features, including size, thickness, internal hyperechoic spots, posterior acoustic shadowing, and Doppler vascularity pattern, are useful for differential diagnosis between high‐risk BCC and cSCC.