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Background  Stratum corneum hydration (SCH) and transepidermal water loss (TEWL) provide useful information about skin barrier function. This study aimed to determine the value of GPSkin Pro, a new handheld device determining both SCH and TEWL, to measure skin barrier impairment and to monitor barrier function in rosacea in daily practice.    Materials and Methods  Two pilots were performed.  Pilot 1 : in 27 healthy participants, GPSkin SCH and TEWL were compared to Aquaflux ®  and Epsilon ®  values at the forearm before and after skin barrier perturbation via tapestripping. Moreover, GPSkin values were measured at both cheeks without intervention.  Pilot 2 : in 16 rosacea patients, GPSkin measurements were performed at the forearm, and at both cheeks before and during anti‐inflammatory treatment. They were compared to clinical symptoms and to GPSkin values from pilot 1.    Results   Pilot 1:  after merging data from before and after tapestripping, a strong correlation was observed between GPSkin TEWL and Aquaflux ®  ( R s   = 0.9256), and GPSkin SCH and Epsilon ®  ( R s   = 0.8798).  Pilot 2:  SCH was significantly lower at the cheeks of rosacea patients compared to controls, with a normalizing trend during successful treatment. TEWL was comparable among patients and controls and did not change during treatment at all locations.    Conclusion  The GPSkin determines TEWL and SCH accurately in healthy and impaired skin barrier state and can monitor skin barrier function in rosacea during treatment. The GPSkin device is much more practical compared to previous skin barrier tools when used in clinical practice. Its further validation in other inflammatory skin diseases is recommended.

Value of GPSkin for the measurement of skin barrier impairment and for monitoring of rosacea treatment in daily practice