Premium
The effect of relaxin on the musculoskeletal system
Author(s) -
Dehghan F.,
Haerian B. S.,
Muniandy S.,
Yusof A.,
Dragoo J. L.,
Salleh N.
Publication year - 2014
Publication title -
scandinavian journal of medicine and science in sports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.575
H-Index - 115
eISSN - 1600-0838
pISSN - 0905-7188
DOI - 10.1111/sms.12149
Subject(s) - relaxin , medicine , hormone , endocrinology , collagenase , fibrosis , tendon , myokine , receptor , bioinformatics , skeletal muscle , biology , anatomy , biochemistry , enzyme
Relaxin is a hormone structurally related to insulin and insulin‐like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling pathways. Relaxin alters the properties of cartilage and tendon by activating collagenase. This hormone is also involved in bone remodeling and healing of injured ligaments and skeletal muscle. In this review, we have summarized the literature on the effect of relaxin in musculoskeletal system to provide a broad perspective for future studies in this field.