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Infection risk in sarcoidosis patients treated with methotrexate compared to azathioprine: A retrospective ‘target trial’ emulated with Swedish real‐world data
Author(s) -
Rossides Marios,
Kullberg Susanna,
Di Giuseppe Daniela,
Eklund Anders,
Grunewald Johan,
Askling Johan,
Arkema Elizabeth V.
Publication year - 2021
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.14001
Subject(s) - medicine , azathioprine , methotrexate , sarcoidosis , retrospective cohort study , disease
The 6‐month infection risk was 43% lower in patients with sarcoidosis who initiated methotrexate compared to those who started azathioprine. Our findings suggest that unless contraindications exist, methotrexate should be preferred over azathioprine as the primary steroid‐sparing choice in individuals with sarcoidosis.