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3D Cohort Study: The Integrated Research Network in Perinatology of Quebec and Eastern Ontario
Author(s) -
Fraser William D.,
Shapiro Gabriel D.,
Audibert François,
Dubois Lise,
Pasquier JeanCharles,
Julien Pierre,
Bérard Anick,
Muckle Gina,
Trasler Jacquetta,
Tremblay Richard E.,
Abenhaim Haim,
Welt Michel,
Bédard MarieJosée,
Bissonnette François,
Bujold Emmanuel,
Gag Robert,
Michaud Jacques L.,
Girard Isabelle,
Moutquin JeanMarie,
Marc Isabelle,
Monnier Patricia,
Séguin Jean R.,
Luo ZhongCheng
Publication year - 2016
Publication title -
paediatric and perinatal epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 88
eISSN - 1365-3016
pISSN - 0269-5022
DOI - 10.1111/ppe.12320
Subject(s) - medicine , psychosocial , cohort , pregnancy , cohort study , obstetrics , pediatrics , family medicine , psychiatry , genetics , pathology , biology
Background The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec and followed along with their children through to 2 years of age. Questionnaires were administered during pregnancy and post‐delivery to collect information on demographics, mental health and life style, medical history, psychosocial measures, diet, infant growth, and neurodevelopment. Information on the delivery and newborn outcomes were abstracted from medical charts. Biological specimens were collected from mothers during each trimester, fathers (once during the pregnancy), and infants (at delivery and 2 years of age) for storage in a biological specimen bank. Results Of the 9864 women screened, 6348 met the eligibility criteria and 2366 women participated in the study (37% of eligible women). Among women in the 3D cohort, 1721 of their partners (1704 biological fathers) agreed to participate (73%). Two thousand two hundred and nineteen participants had a live singleton birth (94%). Prenatal blood and urine samples as well as vaginal secretions were collected for ≥98% of participants, cord blood for 81% of livebirths, and placental tissue for 89% of livebirths. Conclusions The 3D Cohort Study combines a rich bank of multiple biological specimens with extensive clinical, life style, and psychosocial data. This data set is a valuable resource for studying the developmental etiology of birth and early childhood neurodevelopmental outcomes.