English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Lymphocyte‐predominant breast cancer ( LPBC ) defined by the density of stromal lymphocytes shows favorable behavior. However, considerable distribution heterogeneity of lymphocytes is a major problem. The present study defined  LPBC  by the proportion of lymphocyte‐rich stroma with the cut‐off values of 30, 50, and 75%, and clinicopathologically analyzed mainly  LPBC  (area > 30%) defined by the cut‐off value of 30%.  LPBCs  (area > 30%), 39 cases in total, were composed mainly of triple‐negative and HER2 + / ER  ‐  subtypes, without any luminal A‐like subtype.  LPBCs  were composed predominantly of histological grade 3 tumors, without any grade 1 lesions. Multivariate analyses on 477 consecutive tumors revealed that  ER ‐negativity and grade 3 status associated significantly with  LPBC .  LPBC  (area > 30%) showed better disease‐free survival than grade‐matched controls, and it was a good indicator of complete pathological remission after pre‐operative chemotherapy. Patients with  LPBC  with the cut‐off value of 50% and that of 75% showed 100% disease‐free survival. These results demonstrated the validity of our definition of  LPBC . Our data also suggest that de‐differentiated cancers without  TILs  could be regarded as high‐grade cancer without lymphocyte‐mediated responses. In conclusion, the definition of  LPBC  by the proportion of lymphoid stroma is useful for prognostication of high grade breast cancer in routine diagnosis.

Defining lymphocyte‐predominant breast cancer by the proportion of lymphocyte‐rich stroma and its significance in routine histopathological diagnosis