Premium
Proposal for novel histological findings of colorectal liver metastases with preoperative chemotherapy
Author(s) -
Ishida Kazuyuki,
Uesugi Noriyuki,
Hasegawa Yasushi,
Sugimoto Ryo,
Takahara Takeshi,
Otsuka Koki,
Nitta Hiroyuki,
Kawasaki Tomonori,
Wakabayashi Go,
Sugai Tamotsu
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12300
Subject(s) - folfiri , medicine , folfox , bevacizumab , chemotherapy , oxaliplatin , irinotecan , colorectal cancer , oncology , gastroenterology , cancer
This study aimed to clarify the histological characteristics related to preoperative chemotherapy for colorectal liver metastases ( CRLM ). Sixty‐three patients with CRLM were divided into two groups: CRLM with chemotherapy (41 cases, group A ) and CRLM without chemotherapy (22 cases; surgical treatment alone, group S ) to identify the histological differences associated with chemotherapy. In addition, we investigated the effects of combination chemotherapy on the histology of metastatic lesions. Infarct‐like necrosis ( ILN ), three‐zonal changes, and cholesterol clefts were more frequent in group A than in group S ( P < 0.05). ILN and three‐zonal changes were more common in the 5‐FU with leucovorin and oxaliplatin ( FOLFOX ), or 5‐FU with leucovorin and irinotecan ( FOLFIRI ) with or without additional bevacizumab groups than in group S ( P < 0.05). Cholesterol clefts in the FOLFOX or FOLFIRI with bevacizumab group and foamy macrophages in the FOLFOX or FOLFIRI group were more common than in group S ( P < 0.05). Cases with more than three of the four histological findings—i.e. ILN , three‐zonal changes, cholesterol clefts, and foamy macrophages—were more frequent in the FOLFOX or FOLFIRI with or without additional bevacizumab groups than in group S ( P < 0.05). We showed histological findings for every representative chemotherapy regimen for CRLM to clarify the effects of preoperative chemotherapy.